Order pantozol payment otc

Oral, 40 mg per day for up to four weeks

Appropriate studies on the relationship of age to the effects of pantoprazole have not been performed in the pediatric population. Safety and efficacy have not been established. If you experience side effects like dizziness or disturbed vision, you should not drive or operate machines. Clopidogrel: Clopidogrel is metabolized to its active metabolite in part by CYP2C19. In a crossover clinical study, 66 healthy subjects were administered clopidogrel 300 mg loading dose followed by 75 mg per day alone and with pantoprazole 80 mg at the same time as clopidogrel for 5 days. On Day 5, the mean AUC of the active metabolite of clopidogrel was reduced by approximately 14% geometric mean ratio was 86%, with 90% CI of 79 to 93% when pantoprazole was coadministered with clopidogrel as compared to clopidogrel administered alone. Pharmacodynamic parameters were also measured and demonstrated that the change in inhibition of platelet aggregation induced by 5 µM ADP was correlated with the change in the exposure to clopidogrel active metabolite. nortriptyline

Indications and usage of pantozol

Inhibition of gastric acid output and the percent inhibition of stimulated acid output in response to pantoprazole sodium for injection may be higher after repeated doses. What is pantoprazole, and how does it work mechanism of action? Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive. Midazolam HCl has been shown to be incompatible with Y-site administration of pantoprazole sodium for injection. Pantoprazole sodium for injection may not be compatible with products containing zinc. When pantoprazole sodium for injection is administered through a Y-site, immediately stop use if precipitation or discoloration occurs.

What conditions does pantozol treat

Adverse events seen in spontaneous reports of overdose generally reflect the known safety profile of pantoprazole. Pantoprazole delayed-release tablets may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor. Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.

F Protect from freezing and from light

Pantoprazole peak serum concentration C max and area under the serum concentration-time curve AUC increase in a manner proportional to intravenous doses from 10 mg to 80 mg. Pantoprazole does not accumulate and its pharmacokinetics are unaltered with multiple daily dosing. Following the administration of pantoprazole sodium for injection, the serum concentration of pantoprazole declines biexponentially with a terminal elimination half-life of approximately one hour. Serum gastrin concentrations were assessed in two placebo-controlled studies. Pantoprazole sodium for injection is indicated for short-term treatment 7 to 10 days of adult patients with gastroesophageal reflux disease GERD and a history of erosive esophagitis.



What is pantozol

Caucasians and African-Americans and 17 to 23% of Asians. Once gastric acid secretion was controlled, there was no evidence of tolerance during this 7 day study. Basal acid secretion was maintained below target levels for at least 24 hours in all patients and through the end of treatment in these studies 3 to 7 days in all but 1 patient who required a dose adjustment guided by acid output measurements until acid control was achieved. In both studies, doses were adjusted to the individual patient need, but gastric acid secretion was controlled in greater than 80% of patients by a starting regimen of 80 mg q12h. Pantoprazole delayed-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. The CHMP noted that pantoprazole 20 mg was effective in the short-term treatment of reflux symptoms and that there is a long safety experience with the medicine as a prescription medicine. It was also of the opinion that, based on the experience of the use of pantoprazole, the availability of Pantozol Control without medical supervision is appropriate. Kaplan B: Proton pump inhibitors: new drugs and indications. Pantoprazole may stop these and other medicines from working properly. Some medical conditions may interact with pantoprazole delayed-release tablets. The most common side effects with Pantozol Control seen in around 1 patient in 100 are diarrhoea and headache. For the full list of all side effects reported with pantoprazole, see the package leaflet. Use pantoprazole delayed-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures. Pantoprazole delayed-release tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use pantoprazole delayed-release tablets with caution. The stability of the compound in aqueous solution is pH-dependent. For Y-site administration, the in-line filter should be positioned below the Y-site that is closest to the patient. Poor metabolizers exhibited approximately 10-fold lower apparent oral clearance compared to extensive metabolizers. Like all medicines, this medicine can cause side effects, although not everybody gets them. Cleveland Clinic: “Best Day of the Week to Weigh Yourself.



For Intravenous Infusion Only

Swallow tablets whole. Do not break, chew, or crush. There are no data available on the effects of intravenous pantoprazole on ECL cells. This prevents the active substance from being destroyed by the acid in the stomach. Symptomatic response to therapy with pantoprazole does not preclude the presence of gastric malignancy. Treatment with Pantoprazole Sodium for Injection should be discontinued as soon as the patient is able to receive treatment with Pantoprazole Sodium Delayed-Release Tablets or Oral Suspension. If your symptoms do not improve or if they become worse, check with your doctor. Tell your doctor or pharmacist. There are no known symptoms of overdose. The incidence rates of adverse events and laboratory abnormalities in patients aged 65 years and older were similar to those associated with patients younger than 65 years of age. Oral, 20 mg once a day in the morning. Dose can be increased to 40 mg once a day in the morning in the case of recurrence. Pantoprazole is a selective “proton pump inhibitor”, a medicine which reduces the amount of acid produced in your stomach. cefixime



See USP Controlled Room Temperature

The usual dose is one tablet a day. In both studies, pantoprazole sodium for injection 160 or 240 mg per day in divided doses maintained basal acid secretion below target levels in all patients. Caucasians and African-Americans and 17% to 23% of Asians are poor metabolizers. The 20 mg gastro-resistant tablets are light brownish yellow, oval, slightly biconvex tablets. ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested 20 mg to 120 mg. Some MEDICINES MAY INTERACT with pantoprazole delayed-release tablets. Adequate and well-controlled studies in humans have not been done. What is Pantozol Control? During 6 days of repeated administration of pantoprazole sodium for injection in patients with Zollinger-Ellison Syndrome, consistent changes of serum gastrin concentrations from baseline were not observed. Pantoprazole is indicated for short-term up to 8 weeks treatment in patients with active benign gastric ulcer. Approximately 3% of Caucasians and African-Americans and between 17% and 23% of Asians have deficiency of the CYP2C19 hepatic enzyme system, resulting in slow metabolism. Although certain pharmacokinetic values such as half-life and serum concentrations of pantoprazole will be enhanced in these patients, no specific dose adjustments are recommended, and no differences in safety or efficacy are apparent. purchase genuine dapoxetine online dapoxetine



The active substance is pantoprazole

No differences in efficacy or safety between men and women are apparent. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. The reconstituted solution may be stored for up to 2 hours at room temperature prior to further dilution. The admixed solution may be stored for up to 12 hours at room temperature prior to administration. For adult patients who are CYP2C19 poor metabolizers, no dosage adjustment is needed. Keep this leaflet. You may need to read it again. best place florinef online



An increase in liver enzymes

When pantoprazole is taken with food, the time to peak concentration is variable and may be significantly increased. Thrombophlebitis was associated with the administration of intravenous pantoprazole. Product Information: Pantoloc, pantoprazole. Solvay Pharma, Ontario, Canada. Swallow pantoprazole delayed-release tablets whole. Do not break, crush, or chew before swallowing. Oral, 40 mg per day for up to eight weeks. An additional eight-week course may be considered in patients who have not healed after four to eight weeks of treatment. Diabetes Forecast: “Does It Matter When You Exercise? Do not throw away any medicines via wastewater or household waste. GPT mammalian cell-forward gene mutation assay, the in vitro thymidine kinase mutation test with mouse lymphoma L5178Y cells, and the in vivo rat bone marrow cell chromosomal aberration assay. Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. ECL cell hyperplasia and benign and malignant neuroendocrine cell tumors in a dose-related manner. This medicine has been prescribed for you only. Do not pass it on to others. Very high 98%; primarily to albumin. Pantozol Control is used for the short-term treatment of the symptoms of acid reflux in adults. Acid reflux is when acid produced in the stomach escapes into the gullet, causing heartburn and acid regurgitation acid flowing up into the mouth. Why has Pantozol Control been approved? Pantoprazole was more effective than placebo and ranitidine at improving the symptoms of acid reflux. In the first study, 74% of the patients taking pantoprazole 80 out of 108 and 43% of those taking placebo 48 out of 111 had no heartburn after two weeks. Pantoprazole was also more effective than placebo at reducing symptoms of acid regurgitation. In the second study, 70% of the patients taking pantoprazole 121 out of 172 and 59% of those talking ranitidine 102 out of 172 had no heartburn after two weeks of treatment. What is the risk associated with Pantozol Control? In the other study of 14 patients 38 to 67 years; 5 female; 2 Black, 12 White with Zollinger-Ellison Syndrome, treatment was switched from an oral proton pump inhibitor to pantoprazole sodium for injection. Pantoprazole sodium for injection maintained or improved control of gastric acid secretion.



How Long Is an Ideal Nap?

Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties. Protect from light. The reconstituted product should not be frozen. No gender-related differences in the safety profile of intravenous pantoprazole were seen in international trials involving 166 men and 120 women with erosive esophagitis associated with GERD. Pantoprazole doses ³50 mg per kg caused a slight increased frequency of hepatocellular tumor in rats, while in female mice dose of 150 mg per kg also resulted in an increased frequency. However, in both animals, the incidence of hepatocellular tumor was within historical control ranges for the strains tested. The tumors were characterized as late-appearing and primarily benign. Exposure to these unusually large doses for prolonged periods is associated with enzyme induction in rodents, leading to hepatomegaly and centrilobular hypertrophy. These findings not associated with the lower clinical doses and are apparently not applicable to human exposure. Acid secretion returns to normal levels without rebound hypersecretion within 1 week. Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with Zollinger-Ellison Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition. These tablets are not recommended for use in children below 12 years. Long-term treatment eg, longer than 3 years with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor. Although serum half-life values increased to 7 to 9 hours and AUC values increased by 5- to 7-fold in hepatic-impaired patients, these increases were no greater than those observed in CYP2C19 poor metabolizers, where no dosage adjustment is warranted. These pharmacokinetic changes in hepatic-impaired patients result in minimal drug accumulation following once-daily, multiple-dose administration. No dosage adjustment is needed in patients with mild to severe hepatic impairment. The medicine can be obtained without a prescription. How is Pantozol Control used? Pantoprazole is a proton pump inhibitor. It accumulates in the acidic compartment of parietal cells and is converted to the active form, a sulfanilamide, which binds to hydrogen-potassium-ATP-ase at the secretory surface of gastric parietal cells. Inhibition of hydrogen-potassium-ATP-ase blocks the final step of gastric acid production, leading to inhibition of both basal and stimulated acid secretion. The duration of inhibition of acid secretion does not correlate with the much shorter elimination half-life of pantoprazole. Comments: The effects in the nursing infant are unknown. generic eutirox order pharmacy canada



Pantozol warnings

Pantozol Control must not be used in people who are hypersensitive allergic to pantoprazole, soya or any of the other ingredients. Pantoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and to heal. Co-administration of pantoprazole in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA possibly due to a decrease in MMF solubility at an increased gastric pH. The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving pantoprazole sodium for injection and MMF. As an aid to patient consultation, refer to Advice for the Patient, Pantoprazole Systemic. If you have any further questions, ask your doctor or pharmacist. Container: Keep the container tightly closed in order to protect from moisture. Safety and effectiveness of pantoprazole sodium for injection in pediatric patients have not been established. Pantoprazole and its metabolites are excreted in the milk of rats. Pantoprazole excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose. The clinical relevance of this finding is not known. Many drugs which are excreted in human milk have a potential for serious adverse reactions in nursing infants. Based on the potential for tumorigenicity shown for pantoprazole in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. Published observational studies suggest that PPI therapy like pantoprazole sodium may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Pue MA, Laroche J, Meineke I et al: Pharmacokinetics of pantoprazole following single intravenous and oral administration to healthy male subjects. The active substance is pantoprazole. Pantoprazole, by increasing gastric pH, has the potential to affect the bioavailability of any medication for which absorption is pH-dependent. Also, pantoprazole may prevent the degradation of acid-labile drugs. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. In patients with severe renal impairment, pharmacokinetic parameters for pantoprazole were similar to those of healthy subjects. No dosage adjustment is necessary in patients with renal impairment or in patients undergoing hemodialysis. silagra money order now store silagra



General information about pantozol

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Pantoprazole, in combination with clarithromycin and either amoxicillin or metronidazole, is indicated for treatment of patients with an active duodenal ulcer who are H. pylori positive. Andersson T: Pharmacokinetics, metabolism and interactions of acid pump inhibitors: focus on omeprazole, lansoprazole, and pantoprazole. Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of pantoprazole in the elderly. Efficacy and safety are similar to those reported for younger adults. Pantoprazole delayed-release tablets are indicated for the short-term up to 8 weeks treatment of heartburn and other symptoms associated with GERD. Pantoprazole for injection is indicated for the short-term 7 to 10 days treatment of GERD in patients who are unable to continue taking pantoprazole delayed-release tablets. Pantoprazole for injection is not indicated for initial treatment of GERD. Compared to individual subject baseline prior to treatment with pantoprazole sodium for injection. If you suffer from severe liver problems, you should not take more than one 20 mg tablet a day. Pantozol Control is a medicine that contains the active substance pantoprazole. It is available as gastroresistant tablets 20 mg. The active substance in Pantozol Control, pantoprazole, is a proton-pump inhibitor. See Usual adult dose. Thinking and Reasoning: “Time of day effects on problem solving: When the non-optimal is optimal. The clinical significance of this finding is not clear. Since pantoprazole is acid-labile, it is administered as an enteric-coated tablet to prevent gastric decomposition and to increase bioavailability. Tablets should be swallowed whole, and not split, chewed, or crushed. The reconstituted solution may be stored for up to 6 hours at room temperature prior to further dilution. The admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution. Both the reconstituted solution and the admixed solution do not need to be protected from light. Several published observational studies suggest that proton pump inhibitor PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. The risk of fracture was increased in patients who received high-dose, defined as multiple daily doses, and long-term PPI therapy a year or longer. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. alfuzosin



Pantoprazole as a long-term treatment

ECL cell density was apparent after one year among 39 patients, the majority taking 40 to 80 mg pantoprazole for up to 5 years. ECL density appeared to plateau after 4 years. Miller Stage II or III with at least 1 of 3 symptoms typical for reflux esophagitis acid eructation, heartburn, or pain on swallowing were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days. After the initial 5 days, all patients were treated with 40 mg oral pantoprazole daily to complete a total of 8 weeks of treatment. Symptom relief was assessed by calculating the daily mean of the sums of the average scores for these 3 symptoms and the daily mean of the average score for each of the symptoms separately. There was no significant difference in symptom relief between pantoprazole sodium for injection and oral pantoprazole sodium therapy within the first 5 days. A repeat endoscopy after 8 weeks of treatment revealed that 20 out of 23 87% of the pantoprazole sodium for injection plus oral pantoprazole sodium patients and 19 out of 22 86% of the oral pantoprazole sodium patients had endoscopically proven healing of their esophageal lesions. Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy. Pantoprazole sodium for injection is supplied as a sterile, freeze-dried, white to off-white, porous cake or powder containing 40 mg of pantoprazole per vial. Store pantoprazole delayed-release tablets at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep pantoprazole delayed-release tablets out of the reach of children and away from pets. If you have severe liver problems. Please tell your doctor if you have ever had problems with your liver. It is not known whether pantoprazole is distributed into human breast milk.



About pantozol

The FDA approved Pantoprazole in February 2000. Pantoprazole sodium for injection may be administered intravenously through a dedicated line or through a Y-site. If you miss a dose of pantoprazole delayed-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. American Academy of Dermatology: “How to apply sunscreen. Parenteral routes of administration other than intravenous are not recommended. ECL cell hyperplasia and benign and malignant neuroendocrine cell tumors. Dose selection for this study may not have been adequate to comprehensively evaluate the carcinogenic potential of pantoprazole. Study 1 was a multicenter, double-blind, placebo-controlled, study of the pharmacodynamic effects of pantoprazole sodium for injection and oral pantoprazole sodium. In a clinical pharmacology study, pantoprazole 40 mg given orally once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine T 3 thyroxine T 4 thyroid-stimulating hormone, thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin and growth hormone. Pantoprazole has been associated with a small increase in infectious diarrhoea. Check with your pharmacist about how to dispose of unused medicine. In a 5-day study of oral pantoprazole with 40 and 60 mg doses in healthy subjects, following the last dose on day 5, median 24-hour serum gastrin concentrations were elevated by 3 to 4 fold compared to placebo in both 40 and 60 mg dose groups. However, by 24 hours following the last dose, median serum gastrin concentrations for both groups returned to normal levels. This may not be a complete list of all interactions that may occur. Ask your health care provider if pantoprazole delayed-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, extensive CYP2C19 metabolizers, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion. There was no renal excretion of unchanged pantoprazole. wellbutrin price in abu dhabi



Pantozol overdose

The serum protein binding of pantoprazole is about 98%, primarily to albumin. Hurlbut KM Eds: POISINDEXR System. MICROMEDEX, Inc. Use pantoprazole delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing. The incidence rates of adverse reactions were also similar for men and women. Study 2 was a single-center, double-blind, parallel-group study to compare the clinical effects of pantoprazole sodium for injection and oral pantoprazole sodium. Ask your health care provider any questions you may have about how to use pantoprazole delayed-release tablets. casl.info eskazole



Pantozol mail order australia

pantozol purchase online europe, order now cheapest pantozol australia, pantozol canada order, places to buy pantozol, pantozol generic alternative, purchase now generic pantozol shopping, buy pantozol online cheap australia, is canadian pantozol and effective, purchase now cheap pantozol visa, pantozol online australia legal, how long to pantozol, generic pantozol vancouver, buy pantozol online us, price of pantozol brand, pantozol shop amsterdam, buy cheap online pantozol, buy legit pantozol, pantozol tablets in india, buy now pantozol store uk, cheap pantozol buy now store, pantozol mail order payment europe, venta de pantozol, buy pantozol miami, mail order pantozol pharmacy canada, how much does pantozol cost per month, price pantozol qtc, acquisto online pantozol, pantozol canada need prescription, order cheap pantozol payment canada, pantozol generic manufacturers, buy pantozol in hong kong, pantozol compare, how to get a pantozol prescription, pantozol legally uk, best place pantozol online, generic pantozol order pharmacy canada, pantozol price in abu dhabi, pantozol mail order australia, order pantozol payment otc, pantozol money order now store, purchase genuine pantozol online

Highlights for pantozol


Important information

In one study of gastric pH in healthy subjects, pantoprazole was administered orally 40 mg enteric coated tablets or intravenously 40 mg once daily for 5 days and pH was measured for 24 hours following the fifth dose. The placebo group showed a sustained, continuous acid output for 25 hours, validating the reliability of the testing model. Pantoprazole sodium for injection had an onset of antisecretory activity within 15 to 30 minutes of administration. Doses of 20 to 80 mg of pantoprazole sodium for injection substantially reduced the 24-hour cumulative PSAO in a dose-dependent manner, despite a short plasma elimination half-life. Complete suppression of PSAO was achieved with 80 mg within approximately 2 hours and no further significant suppression was seen with 120 mg. The duration of action of pantoprazole sodium for injection was 24 hours. order diclofenac payment otc

What are the side effects of pantoprazole?

Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation. Oral, 40 mg per day for up to two weeks. Keep this medicine out of the sight and reach of children. Pantoprazole sodium for injection 40 mg once daily does not raise gastric pH to levels sufficient to contribute to the treatment of such life-threatening conditions. misoprostol

Oral, 40 mg per day for up to two weeks

See USP Controlled Room Temperature. This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk. Do not take a double dose to make up for a forgotten dose. Take your next normal dose at the usual time. H-benzimidazole, a compound that inhibits gastric acid secretion. Its molecular formula is C 16H 14F 2N 3NaO 4S, with a molecular weight of 405. isoptin mail order australia

Reviews for pantozol

The data from these studies revealed that animals in both age groups respond to pantoprazole in a similar manner. No adverse effects were reported in single-agent overdose with pantoprazole in doses of 400 and 600 mg. Death following multi-agent ingestion was attributed to chloroquine and zopiclone rather than pantoprazole. Due to extensive protein binding, pantoprazole is not readily dialyzable.

European Union EU called Pantozol. What is Pantozol Control used for? After first opening of the container, the product should be used within 3 months. Stevens-Johnson-Syndrome, Lyell-Syndrome, Erythema multiforme and sensitivity to light. By blocking the pumps, pantoprazole reduces acid production, relieving the symptoms of acid reflux. ECL-cell proliferation and gastric neuroendocrine NE-cell tumors. Gastric NE-cell tumors in rats may result from chronic elevation of serum gastrin concentrations. The high density of ECL cells in the rat stomach makes this species highly susceptible to the proliferative effects of elevated gastrin concentrations produced by proton pump inhibitors.

Learn more »